2023-11-04

[public] 541K views, 39.1K likes, dislikes audio only

Chubbyemu

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Patient JC by Chad Collins, PA Tristyn Smith, Special Thanks to Jena Marx

Music by @Lifeformed ► https://lifeformed.bandcamp.com

More music by T4N3 ► https://soundcloud.com/t4n3

Good Playlist ► https://www.youtube.com/playlist?list=PL26HeTCO57qcMQB6CrU6QRzEi9tt9l1FI

Timestamps:

0:00 A Bodybuilder 💪 Mistook An Aphrodisiac 😳 for Pre-Workout Supplement

0:22 JC was getting ready 🏋️ for a show

0:55 A wild 😲 supplement appears

1:35 Hey IRS 💵 we doing research 👨‍🔬 and development

1:50 Good ☁️ powder

2:16 haha preworkout 💪 go glug 😳 glug

3:13 The emergency 🚑 room where we are now

4:07 How does 🌳 do all of these??

4:50 Rumors of this toxicity... are not exaggerated at all. It's not good.

5:50 Neuro 🧠 transmitters gotta 😳 go 😲 fast

6:48 Inside you(r autonomic nervous system) are 2 wolves (just kidding, they're more nervous systems)

7:27 What happens 😳 here?

8:16 Alpha vs beta (not alpha male vs beta male)

9:11 In the central nervous system

9:47 Feedback 🛑 mechanism (in normal function)

10:51 The CEO of systemic... response to adrenergic agents

11:35 Multiple reports in existence

12:02 "Just pull it out of his body bro"

12:23 An Antidote 🐴 But How 🤔 Did We Find It?

14:45 Yea lets not use that here, but we could use something else

15:15 It takes 5 half lives to reach steady state, but Half Life 3 still isn't 😞 here

I don't think anyone reads anything that's written here. But here's for the metadata: this video is explicitly about adrenergic receptors. More specifically, the Alpha subtype, and even more specifically, Alpha 2 Adrenergic Receptors. This thing throws a massive curveball to learners in all medical disciplines because Alpha 2 agonism / antagonism are opposite of Alpha 1. The topic of these receptors can be a few weeks long in a Pharm course in Medical and Pharmacy schools, and that course would be dedicated specifically to cardiac pharmacology, so this is as much I can cover in an 18 minute video. There might be people who will go "nooooo u cant just say that about my tree bark supplement" but the point is and has always been to teach about the pharmacology, its mechanism and how the setting of excess changes the pharmacokinetics-- the agent serves as a means for me to teach that because it has that activity. If it didn't have that activity, I'd talk about something else that does in this setting. It's a fascinating molecule, like all natural products. If you don't need to ingest it, don't ingest it, but I trust you are well in your best capacity to make decisions for yourself.

These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.

References:

Acute neurotoxicity after yohimbine ingestion by a bodybuilder. https://pubmed.ncbi.nlm.nih.gov/19640235/

Yohimbine: a clinical review. https://pubmed.ncbi.nlm.nih.gov/11744068/

Alpha-2 Adrenoreceptor Antagonist Yohimbine Potentiates Consolidation of Conditioned Fear. https://academic.oup.com/ijnp/article/25/9/759/6617231

Adrenergic receptors: structure and function. https://pubmed.ncbi.nlm.nih.gov/2164898

Biopharmaceutics and metabolism of yohimbine in humans. https://pubmed.ncbi.nlm.nih.gov/10494000/

Yohimbe bark extract. https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/chem_background/exsumpdf/yohimbe_508.pdf

Yohimbine or NO-himbine? A Potentially Fatal Over-the-Counter Supplement. https://www.vumc.org/poison-control/toxicology-question-week/feb-15-2022-yohimbine-or-no-himbine-potentially-fatal-over-counter

[PREPRINT] Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to naloxone administration. https://www.biorxiv.org/content/10.1101/2023.09.08.556914v1

Xylazine, an Emerging Adulterant. https://www.acep.org/talem/newsroom/oct-2021/xylazine-an-emerging-adulterant

Yohimbine. https://pubmed.ncbi.nlm.nih.gov/4037464/