2019-12-01

[public] 2.34M views, 77.1K likes, 1.13K dislikes audio only

Chubbyemu

Please take care when eating leftovers and when preparing food with copper utensils🍴

Medicine (full playlist) ► https://www.youtube.com/playlist?list=PL26HeTCO57qcMQB6CrU6QRzEi9tt9l1FI

Reviewer: Dr. Joe Akin

A Better Way to Make Pickles ► https://www.youtube.com/watch?v=vD6XWXj9l8Q

Check out the music by Lifeformed ► https://lifeformed.bandcamp.com

Another Better Way to Make Pickles ► https://www.youtube.com/watch?v=ajzArdLK6tE

3-Day Potato Salad ► https://www.youtube.com/watch?v=5Ugrgl9tB2s

Toxicology (full playlist) ► https://www.youtube.com/playlist?list=PL26HeTCO57qe9SS_dttfWVHL8boBWxJGp

A Student Ate 5 Day Old Pasta For Lunch. This Is How His Liver Shut Down. ► /youtube/video/5ujTYLV2Qo4

A Student Ate Gas Station Sushi For Breakfast. This Is What Happened To His Stomach. ► /youtube/video/HtZi7nj-WYw

A Chef Ate Gas Station Nachos For Dinner. This Is What Happened To His Limbs. ► /youtube/video/KNb_MoqxA5o

This is a case about Wilson's Disease. Wilson's Disease is a genetic disorder with an autosomal recessive inheritance pattern affecting the ATP7b gene on chromosome 13. The inherited genetic defect prevents the correct production of the ATP7b protein, which is a copper transporter, meaning the body's ability to transport copper is impaired. Causing copper to build up. Causing damage to the liver cells by creating reactive oxidative species and forming a sludge in the gallbladder as the acute liver failure in CG causes permanent damage. Autosomal recessive means that in a family pedigree, it can often be seen as "skipping" a generation, as more carriers for Wilson's are introduced into the population.

As the copper spills into the bloodstream, it enters the brain. In normal function, the same protein as found in the liver also transports copper out. But because of the genetic defect, that doesn’t happen. Copper accumulates in the brain, and this metal toxicity begins to damage nerve cells, showing up as motor dysfunction in CG.

Treatment for Wilson's disease when caught early is zinc, which will prevent the body from absorbing copper from daily intake. In acute hypercupremia and liver failure, the only treatment is liver transplant. The qualification of acute hepatic failure is important in placing the patient on the wait list for a liver.

These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet, see your own physician in person for that.

References:

Dr. Akin prepared a Refigure for you to understand more about the disease pathophysiology here: http://bit.ly/wilsondisease

-Hepatology. 2008 Apr; 47(4): 1401–1415. PMID: 18318440

-Causes and Pathophysiology of Vitamin B12 and folate deficiencies - UpToDate

-Overview of dietary trace minerals - UpToDate

-National Research Council (US) Committee on Copper in Drinking Water. Copper in Drinking Water. Washington (DC): National Academies Press (US); 2000. 5, Health Effects of Excess Copper.

-Nat Med. 2007 Feb;13(2):164-70. PMID 17259995

-Wilson disease Epidemiology and pathogenesis - UpToDate

-Wilson disease Treatment and prognosis - UpToDate

-Wilson disease Diagnostic tests - UpToDate

-Lancet Neurol. 2015 Jan; 14(1): 103–113. PMID 25496901

-Hepatology. 2008 Jun;47(6):2089-111. PMID 18506894

-Int J Biochem Cell Biol. 1998 Oct;30(10):1063-7. PMID 9785470

-Revised King's College score for liver transplantation in adult patients with Wilson's disease. Liver Transpl. 2007 Jan;13(1):55-61. PMID 17154398

-N Engl J Med. 2017 Jan 19;376(3):268-278. PMID 28099829