Simulating the Evolution of Aging

2025-02-01

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Patreon:

https://www.patreon.com/primerlearning

Ageless book: https://ageless.link/

Andrew Steele on YT: https://www.youtube.com/@DrAndrewSteele

Papers and other further reading:

Diversity of aging across the tree of life: https://pmc.ncbi.nlm.nih.gov/articles/PMC4157354/

Antagonistic pleiotropy and p53: https://pmc.ncbi.nlm.nih.gov/articles/PMC2771578/

An unsolved problem of biology (Medawar): https://ia903408.us.archive.org/31/items/medawar-1952-unsolved-problem/Medawar1952-Unsolved-Problem.pdf

Evolution of the mutation rate: https://pmc.ncbi.nlm.nih.gov/articles/PMC2910838/

Our World in Data Life Expectancy explainer: https://ourworldindata.org/life-expectancy-how-is-it-calculated-and-how-should-it-be-interpreted

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Music by Mathieu Keith. For business inquiries: mathieu.keith@proton.me

00:00 Introduction and outline

00:43 In which I beg for money

03:05 Simulation rules

04:09 Analyzing lifespans with no aging

09:19 Simple death genes

14:43 Mutation accumulation

26:58 Antagonistic pleiotropy

29:59 Review

30:21 Recommendations

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