Aspirin to Acetaminophen - Part 4 of 6: Mono-nitration of Phenol

2016-12-15

[public] 82.6K views, 2.34K likes, 11.0 dislikes audio only

We are back again for the fourth installment! We will be doing the mono nitration of phenol, to get a mixture of p-nitrophenol and o-nitrophenol. The o-nitrophenol is separated off by steam distillation and the p-nitrophenol that is left over is cleaned by recrystallization.

This video turned out to be very long and it took me like 25 hours to edit it...so you should definitely watch all of it.

Also, acetaminophen = Paracetamol = Tylenol = APAP

Links:

• Prepchem procedure: http://www.prepchem.com/synthesis-of-4-nitrophenol/

• Other prep I found: http://www.oc-praktikum.de/nop/en/instructions/pdf/5001_en.pdf

• Picric acid: https://youtu.be/pIsf2TqVbQA

• Chemplayer mono-nitration: https://youtu.be/8KamkN22c-4

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