Why We Can't Deliver Drugs to the Brain

2016-06-16

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Why your brain says no to drugs: Meet the blood-brain barrier.

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BrainCraft is created, written and hosted by Vanessa Hill (@nessyhill) and brought to you by PBS Digital Studios. Talking psychology, neuroscience & why we act the way we do.

Produced, Hosted and Edited by Vanessa Hill

Written by Rachel Tsunemoto http://www.rtsunemoto.com/

Animation by Vanessa Hill and Rachel Tsunemoto

Sound design by Joel Werner http://joelwerner.com

More BrainCraft: What's The Value of a Life? /youtube/video/XarO3VoNwmc

REFERENCES

Dressler, D., & Adib Saberi, F. (2005). Botulinum toxin: mechanisms of action.European neurology, 53(1), 3-9. http://www.ncbi.nlm.nih.gov/pubmed/15830090

Siegel, G. J., Agranoff, B. W., Albers, R. W., Fisher, S. K., & Uhler, M. D. (1999). Basic neurochemistry. http://www.ncbi.nlm.nih.gov/books/NBK28180/figure/A2323/?report=objectonly,

Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006). Astrocyte–endothelial interactions at the blood–brain barrier. Nature Reviews Neuroscience, 7(1), 41-53. http://www.nature.com/nrn/journal/v7/n1/fig_tab/nrn1824_F3.html

Chen, Y., & Liu, L. (2012). Modern methods for delivery of drugs across the blood–brain barrier. Advanced drug delivery reviews, 64(7), 640-665. http://www.sciencedirect.com/science/article/pii/S0169409X11002900

Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016). Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases. Journal of Controlled Release,235, 34-47. http://www.sciencedirect.com/science/article/pii/S0168365916303236

Tiny bubbles: https://www.newscientist.com/article/mg22229742-400-human-brains-ultimate-barrier-to-open-for-first-time/